Skip to content. Castro-Lowenstein Lab. Bibliography on PubMed. Michigan Research Experts Profile. Maria G. Castro, PhD , is the R.
Student Thesis Defenses
Our Lab – OBENAUF LAB
The initiation, progression, and metastasis of tumors involve not only cancer cells, but also the tumor microenvironment, which consists of immune or inflammatory cells, fibroblasts, endothelial cells, and extracellular matrix components ECM. Fibroblasts are ubiquitous stromal cells that can influence other neighboring cell types through the secretion of chemokines, cytokines, ECM, ECM remodeling enzymes, and other metabolites. These cells are a dominant component of the microenvironment, and a FSP1 and FAP could be a different clone of fibroblasts. Myofibroblasts also have been known to contribute to cancer progression and metastasis in multiple cancer types including breast and pancreas cancer, both of which are associated with extensive desmoplasia. Intraluminal tumor burden appeared reduced in myofibroblast-depleted tumors; however, the tumors were depressed resulting in more invasion to both the vascular and lymphatic vessels.
Single Cell Analysis Boot Camp: Systems Biology Methods for Analysis of Single Cell RNA-Seq
The research projects of PhD students participating in the Cell Migration program deal with questions related to. A cell migration in immunosurveillance and inflammation B cell migration in tumorigenesis and metastasis C the influence of soluble Factors in cell migration. Mounting a specific immune response requires the timely interaction of various immune cell types within secondary lymphoid organs. Studies on the regulation and function of homing receptors in T lymphocytes and on how these receptors orchestrate cell positioning and interactions with other immune cells in secondary lymphoid tissues are central to our understanding of immune responses.
Denis Nastic Improving endometrial carcinoma diagnostics April 27, Abstract and thesis. Christian Oertlin Developing analytical tools to investigate the role of translation in homeostasis and disease April 23, Abstract and thesis. Ziqing Chen From natural to eximious: harnessing the power of natural killer cells against solid tumors April 23, Abstract and thesis. Fernanda Costa Svedman Molecular markers for prediction of response and progression free survival to novel therapies in cutaneous malignant melanoma March 19, Abstract and thesis. Anna Lewandowska Ronnegren Crosstalk between environmental signals and 3d genome organization in the regulation of gene expression February 12, Abstract and thesis.